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chondroitin msm

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Chemical strucutre of α-D-glucosamine

Glucosamine (C₆H₁₄NO₅) is a dietary supplement distributed as a salt — usually as glucosamine HCl, glucosamine sulfate potassium, or glucosamine sulfate sodium. A typical dosage is 1,500 mg per day. The salt complexes, glucosamine sulfate _* KCl or glucosamine sulfate _* NaCl, or the hydrochloride, glucosamine sulfate _* HCl, are required for stabiliity.

Glucosamine sulfate is a synthetic version of a compound the human body makes to stimulate the growth of cartilage. The idea is that such compounds help rebuild cartilage and reduce the symptoms of arthritis.

The supplement is an acceptable treatment in veterinary medicine, but the Arthritis Foundation and the American College of Rheumatology have not yet officially recommended it for humans, despite a large body of evidence supporting its use and the fact that it is considered a drug in several countries around the world. The United States Food and Drug Administration does not approve any dietary supplement, and, as such, at this time glucosamine is sold as a nutritional supplement and therefore does not need evidence of safety and efficacy. Glucosamine has been studied for over 20 years. As a natural substance that is already present inside the body, evidence bears out that glucosamine appears to be quite safe. One caveat - there is limited evidence that individuals with an allergy to shellfish should avoid glucosamine, as it is is usually derived from shellfish. There are vegetarian sources available.

Current research shows it does not play a role in relieving pain associated with osteoarthritis. As used, it is often paired with MSM. The National Institutes of Health conducted a multi-arm, placebo-controlled study to test the effects of chondroitin and glucosamine on osteoporosis and osteoarthritis. The results of this 6-month clinical trial found that patients taking glucosamine, chondroitin or a combination of the two had no statistically significant improvement in their symptoms than patients taking a placebo. The control group of patients who took celecoxib had a statistically significant improvement in their symptoms. These results indicate that glucosamine and chondroitin do not effectively relieve osteoarthiritic pain. Although the study found no overall effect for the supplements, analysis of a subgroup of patients suggests that the supplements taken together might help some people with more severe pain.

External links

• The Glucosamine and Arthritis Information Center (Funded by DTC Health Inc., the makers of Flexicose, a liquid glucosamine supplement.)
• NIH 'Questions and Answers: NIH Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)'
• "Supplements Fail to Stop Arthritis Pain, Study Says," New York Times, February 23, 2006.

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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "glucosamine".